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화학요법제 합성연구 III Thiosemicarbazone 유도체의 합성 및 항균성

Synthetic Studies on Chemotherapeutic Agents. III. Synthesis and Antimicrobial Activity of Some Thiosemicarbazone Derivatives

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Seventeen novel compounds of thiosemicarbazone derivatives were synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv and antibacterial activity against Staphylococcus aureus, Escherichia coli. It was found that 4-(alpha-naphthyl)-1-(2-furfuraldehyde)-3-thiosemicarbazone was active at 0.01mcg/ml against E.Coli, respectively.

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