4,4-Pentamethylene-1,3-oxazolidine-5-one-2-thione에 관한 연구

Study on 4,4-Pentamethylene-1,3-oxazolidine-5-one 2-thione

4,4-Pentamethylene-1, 3-oxazolidine-5-one-2-thione is to be obtained from 1-amino cyclohexane carboxylic acid and thiophosgene, however, it was not isolated because of its unstability. When it was treated with C6H5NH2, N-phenyl-(1-aminocyclohexane) carboxylic acid and N-(1-carboxycyclohexyl), N-phenyl thiourea were obtained. When refluxed in H2O at pH 2, pH 12 and neutral condition, the resulting carboxylic compound, being anticipated by us, was 1-aminocyclohexane carboxylic acid. From the above results, we have got the suggestion of the chemical behavior of 4,4-pentamethylene-1,3-oxazolidine-5-one-2-thione and also some imformations of the reaction mechanism between 1-aminocyclohexane carboxylic acid and thiophosgene.