2,2''-Methylene bis(3,4,6-trichlorophenoxyacetic acid)의 Mannich Bases합성 및 항균작용에 관한 연구

Studies on the Synthesis of Mannich Bases of 2,2''-Methylene bis(3,4,6-trichlorophenoxyacetic acid) and their Antimicrobial Activities

Thirty-three Mannich bases of 2,2''-methylene bis(3,4,6-trichlorophenoxyacetic acid) were synthesized as potential antimicrobial agents and tested against. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Trichophyton rubrum, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger and Aspergillus oryzae in vitro. It was found that: 1) Compounds 24 and 22 were active against Staphylococcus aureus and Bacillus subtilis at the concn. of 1 mcg/ml respectively; 2) Compounds 9 and 29 were active against Trichophyton rubrum at the concn. of 2mcg/ml, respectively; 3) Compounds 9 and 3O were active against Microsporum gypseum at the concn. of 2mcg/ml respectively; 4) Compounds 6, 9, 13, 15, 21, 28, 29, 31, 33 and 34 were active against Epidermophyton floccosum at the concn. of 1mcg/ml respectively; 5) Compounds 6, 9, 18 and 28 were active against Aspergillus niger and Aspergillus oryzae at the concn. of 1mcg/ml respectively.