Formamidine 종의 합성 및 살균성

Studies on the Synthesis and Bactericidal Activity of Formamidines

Six novel compounds of N,N-dimethyl-N''-(6-substituted-2-benzothiazolyl) formamidines and six novel compounds of N,N-dimethyl-N''-(substituted-phenyl)formamidines were synthesized. They were evaluated for their bactericidal activities against Salmonella typhosa, Escherichia coli, Vibrio cholera, Staphylococcus aureus, Sarcina lutea and for their fungicidal activities against Saccharomyces cereviseae, Candida albicans. It was found that these compounds were considerably more active than phenol, especially against Vibrio cholera, and N,N-dimethyl-N''-(4-methyl-phenyl)formamidine, N,N-dimethyl-N''-(2-methyl-4-bromo-phenyl)formanidine showed most potent bactericidal activities.