학술저널
제암성물질의 합성에 관한 연구 VI. 2,4-Dihydroxy-5-nitropropiophenone 유도체의 합성 및 항종양시험
Studies on the Synthesis of Antineoplastic Agents. VI. Synthesis and Antineoplastic Activity of 2,4-Dihydroxy-5-nitropropiophenone Derivatives.
- 대한약학회
- 약학회지
- 제17권 제2호 (1973년)
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1973.06115 - 121 (7 pages)
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Seven beta-substituted-2, 4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the synthesized compounds, beta-(1-methyl-1-hydroxymethyl) ethylamino-2,4-dihydroxy-5-nitropropiophenone, beta-(1,1-dihydroxymethyl) ethylamino-2, 4-dihydroxy-5-nitropropiophenone and beta-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.
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