학술저널
Specific Association of Riboflavin and Penicillin Derivatives in Chloroform Solution
- 대한약학회
- 약학회지
- 제18권 제3호 (1974년)
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1974.09209 - 216 (8 pages)
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From the measurements of infrared and fluorescence spectra riboflavin-2'',3'',4'',5''-tetraacetate has been found to associate with penicillin-V more than strongly with themselves. They form the 1 : 1 cyclic hydrogen bonded dimer through the imino and the 2-C carbonyl groups of the isoalloxazine ring and the imino group of the penicillin-V ressidue. Penicillin-V is an effective quencher of the fluorescence of riboflavin tetraacetate. The quenching appears mainly due to the coplanar interction through hydrogen bonds partly due to the collision interaction with the penicillin ring.
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