학술저널
2-Aryl-3-(5-nitro-2-furyl) acrylamide류의 합성과 항균작용에 관한 연구
Studies on the Synthesis and Antimicrobial Activity of 2-Aryl-3-(5-nitro-2-furyl) acrylamides
- 대한약학회
- 약학회지
- 제18권 제4호 (1974년)
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1974.12249 - 254 (6 pages)
- 2
Eighteen 2-aryl-3-(5-nitro-2-furyl) acrylamides were synthesized as antimicrobial agent, by the condensation of 2-(p-substituted phenyl)-3-(5-nitro-2-furyl) acryloyl chloride with amino component, such as sulfisoxazole, sulfamethoxypyridazine and sulfadimethoxine. All compounds showed fair bacteriostatic activity against Staphylococcus aureus 6538p, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae. 2-(p-Hydroxyphenyl)- and 2-(p-acetoxyphenyl) compounds also showed antimicrobial activity against Saccharomyces cerevisiae 396 and Aspergillus oryzae.
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