아질산염이 백서의 간 및 뇌조직중 인지질조성에 미치는 영향

Effects on the Phospholipid Patterns of Liver- and Brain-Tissues of Albino Rats Treated with Sodium Nitrite.

The amount of total lipids and phospholipids in the rat liver and brain after sodium nitrite treatment was measured together with the composition ratio of phospholipids. The results obtained were as follows-. 1) The amount of total lipids and phospholipids was decreased significantly and this decrease was more outstanding in the rat brain than liver. 2) The amount of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin was decreased, whereas that of phosphatidylinositol and diphosphatidylglycerol increased. According to the above described results, it appears that the sodium nitrite treatment of 120mg/kg/day concentration brings inhibition of lipid metabolism in the rat liver and brain.