학술저널
Cinmetacin 유도체의 합성과 진통항염활성
Synthesis and Analgesic-antiinflammatory Activity of Cinmetacin Derivatives
- 대한약학회
- 약학회지
- 제45권 제1호 (2001년)
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2001.021 - 6 (6 pages)
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Nine cinmetain derivatives as potential nonsteroidal analgesic and antiinflammatory compounds were prepared and their analgesic-antiinflammatory activity was compared with conmetacin. Salicylic acid and phenols were reacted with dicyclohexyl carbodiimide (DCC) to give phenyl salicylates (1-4). Cinmetacin was treated with DCC and phenol derivatives to yield cinmetacin esters (5-13). Compounds(5, 7, 8, 10, 12, and 13) showed stronger analgesic activity than cinmetacin, but only compound (5) showed comparable antiinflammatory to cinmetacin.
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