이온교환체로서 금속-페난드롤린-메페남산 3원 착물을 이용한 메페남산의 정량

Determination of Mefenamic acid with ISEs using Ternary complex of Metal-phenanthroline-mefenamate as Ion-exchanger

A method for the determination of anionic drug, mefenamate with ion-selective electrode using Fe(II)-1,10-phenanthroline chelate as a counter ion was developed. Benzyl nitrophenyl ether (BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. This membrane electrode exhibits a linear response for 10-2 M~5 ×10-5 M of mefenamic acid with a slope of - 61.4mV/dec. in borate buffer sloutions (Ph 9.0). Potentiometric selectivity measurements revealed negligible interferences from various organic and ionorganic anions. Direct potentiometry and potentiometric titration method of mefenamic acid in capsule preparations are presented and compared.