SHR에 있어 Enalapril의 ACE 억제효과에 대한 Ginkgo biloba Extract(EGb 761)의 영향

Effects of Ginkgo biloba Extract (EGb 761) on the Enalapril-induced ACE Inhibition in SHRs

Drug inetraction between of enalapril-induced angiotensin converting enzyme (ACE) inhibitory effect and Ginkgo biloba Ext.-induceed antioxidant action evaluated in spontaneously hyperensive rats. Combination treatment of enalapril (20mg/kg/day,p.o.) and Ginkgo biloba Ext. (60mg/kg/day,p.o.) for 6 weeks in drinking water to SHRs resulted the inhibition of ACE activity in lung tissue, angiotensin I-induced pressure reponse and plasma angiotensin II concentration as similar to enalarpril alone treatmeant. But these effects were sustained after 1 week withdrawal of enalapril and Ginkgo biloba Ext. co-administeration. Also, coadministered group did not increse the concentration of bradykinin in lung tissue, which were different from enalapril alone treated group. Co-administration of enalapril and Ginkgo biloba Ext. inhibited the hemolysis induced by UV B type, eyen Ginkgo biloba Ext. alone treated group did not. These results suggested that Ginkgo biloba Ext. sustained ACE inhibitory dffect and reduced the inhibitiry effect of bradykinin inactivation induceed by enalapril, meanwhile, enalapril increased the antioxidant effect of Ginkgo biloba Ext.