녹차카테킨과 에피갈로카테킨갈레이트의 산화적 스트레스에 대한 억제효과

Protective Effects of Green Tea Catechins and (-)-Epigallocatechin gallate on Reactive Oxygen Species-Induced Oxidative Stress

Green tea catechins (GTC) and its major component, (-)-epigallocatechin gallate (EGCG) were studied for their protective effect against reactive oxygen species (ROS)-induced oxidative stress. GTC and EGCG showed the strong antioxidative effects on the lipid peroxidation of ethyl linolate with Fenton's reagent and free radical scavenging effect to DPPH radical generation. They also protected H2O2-or KO2-induced cytotoxicity in CHL cells or mouse splenocytes. These results indicate that GTC and EGCG are acpable of protecting the lipid peroxidation, free radical generation and cytotoxicity induced by ROS. The mechanism of inhibition in ROS-induced cytotoxicity may be due to their antioxidative and free radial scavenging properties. Therefore, GTC and EGCG may be useful chemopreventive agents by protecting the free radical generation which are involved in cancer and aging.