유향물추출물의 HL-60 혈액암세포에서 세포사멸 유도효과

The water extract of Bowellia carterii induced apotosis in human leukemmia HL-60

The possible mechanism of the antiproliferative and apoptotic effects of Boswellia carterii water extract were studied in HL-60 human leukemia cells. The cytotoxicity of HL-60 cells after the treatment of Boswellia carterii water extract showed dose- and time-dependent manner. The appototic effect of 300 mcg/ml Boswellia carterii water extract was demonstrated by DNA laddering. The activity of capase 3-like protease was markedly increased in HL-60 cells treated with Boswellia carterii water extract. Furthermore, the level of Bcl-2 was time-dependently reduced, whereas Bax protein level was enhanced by Boswellia carterii water extract treatment. In conclusion, our results suggest that apoptotic effect of Boswellia carterii water extract treatment. In conclusion, our results suggest apototic effect of Boswellia carterii water extract may partly mediated through activations of capase-3-activity, and Bax expression, and inhibition of Bcl-2 expression.