한국산 겨우살이 (Viscum album coloratum)로부터 정제된 렉틴 성분 KML-IIU의 예비 독성 및 일반 약리 시험

Preliminary Tlxicity and General Pharmacology of KML-IIU, a Purified Lectin from Korean Mistletoe (Viscum album coloratum)

The study was carried out to evaluate the preliminary toxicity and general pharmacology of KML-IIU, a purified lectin com Korean Mistletoe (Visum album coloratum). KML-IIU was administered intravenously to ICR mice and Spargue-Dawley rats to investigate the acute toxicity. LD5O values in mice and rats were above 30mcg/kg. KML-IIU had no effects on the general behaviors, acetic acid induced writh- ing syndrome, pentobarbial induced sleeping time, pentylenetetrazole induced convulsion and the change of body temperature. In addition, KML-IIU did not show any effects on digestive system and blood coagulation system.