학술저널
헤테로환성 아민기를 갖는 신규 택솔유도체의 합성
Synthesis of Novel Taxol Analogues with Heterocylclic Amino Moieties
- 대한약학회
- 약학회지
- 제45권 제4호 (2001년)
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2001.08321 - 327 (7 pages)
- 5
The synthesis of novel taxol analogues with an amiRe moiety at the 7- and 10-positions to examine the BBB penetration was described. The analogues were synthesized from 2'- 0- (tert-butyldim-ethylsilyl)taxol and 2'-0- (text- butyldimethylsilyl)-7-0- (triethylsilyl)-10-deacetyltaxol, the key intermediates, in 2 steps via the esterification with heterocyclic amino acids and the subsequent desilylation reaction.
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