Dopamine D2 Receptor 효능제인 TNPA의 중추적 항이뇨작용 기전

The Mechanism of Central Antidiuretic Action Induced by TNPA, Dopamine D2 Receptor Agonist, in Dogs

It has been demonstrated previously that R(-)-2,10,11-trihydroxy-N-n-propylnora porphine (TNPA), a dopamine D2 receptor agonist, produced the antidiuresis through changes of central function in dog. This study was investigated about effects of renal denervation and raclopride, a dopamine D2 receptor antagonist, on the antidiuresis of TNPA in order to elicidate the mechanism involved in this central anticiuresis induced by TNPA. Antidiresis exhibited by mPh given into the vein or into carotid artery was not influenced by renal denervation, whereas antidiuresis of TNPA administered into carotid artery was blocked almost perfectly by raclopride pretreated into carotid artery: From these observations it is concluded that central antidiuresis induced by TNPA is brought about through activation of dopamine D2 recap- tor localized in brain, not related to renal nerve activity.