학술저널
Bak-like단백질을 code하는 cDNA의 동정
Identification of Bak-like Protein cDNA
- 대한약학회
- 약학회지
- 제45권 제4호 (2001년)
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2001.08426 - 430 (5 pages)
- 6
Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Bak, a member of the Bcl-2 protein fami1y; accelerates apoptosis by an unknown mechanism. We have found a novel cDNA encoding a 101 amino acid protein possessing a Bak-like in our full-length cDNA bank. Bak-like shares the conserved domains BHI and 2 with other proapoptotic proteins but lacks the BH3 domain. Bak-like is expressed in a wide variety of tissues. Like Bak, Bak-like gene product primarily enhances apoptotic cell death following an appropriate stimulus.
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