케토프로펜 패취제의 제제설계 및 피부 투과 특성

Formulation and Skin Permeation Characteristics of Ketoprofen Patches

Ketoprofen (KP) was formulated as a transdermal patch using the percutaneous penetration enhancers sorbitan monooleate (SMO), polyvinylpyrrolidone (PVP). The control patch without penetration enhancers showed a KP flux of 8.9 +/- 0.75 μg/cm2/h. The flux was increased in proportion to the concentration of SMO added. Furthermore, lag times were decreased upon addition of SMO. Conversely, the skin flux of KP was decreased in proportion to the concentration of PVP added. Pharmacokinetic parameters including Cmax, Tmax, and AUC were increased when SMO was added. However, Cmax was signifcantly decreased by the addition of PVP Tmax was not significantly different in 2%, 4%, and 8% PVP patches. Patches containing 4% PVP showed the highest AUC value (19.158μg ·h/ml). We found that the effectiveness of the two percutaneous penetration enhancers for topical KP patches was similar, with the addition of appropriate amounts of HPC modifying both skin flux and lag time of KP in the patches. In conclusion, it is possible to manufacture KP patches exhibiting high AUC, high skin flux, and short lag time using percutaneous penetration enhancers of SMO and PVP.