황기의 저밀도지질단백질(LDL)산화에 미치는 영향

Effect of Astragali Radix on Low Density Lipoprotein Oxidation

The root of Astrogalus membranaceus Bunge (Leguminosae), which has been used for the treatment of hypertension, chronic hepatitis, duodenal ulcers, chronic nephritis and promotion of immunity in folk remedies. Several lines of evidence indicate that oxidative modification of low-density lipoprotein (Ox-LDL) may play an important role in atherogenesis. Hence, the role of antioxidants in the prevention of LDL oxidation needs to be determined. To investigate the antioxidant activity we determined the MeOH ex. And fractions of Astragali Radix on the inhibition of LDL oxidation. The CH2Cl2 and EtOAc frations inhibited the oxidative modification of LDL by a decrease in the lipid peroxide content and the electrophoretic mobility of LDL. Calycosin-7-0-β-D -glucoside which was isolated from EtOAc fraction inhibits the oxidative modification of LDL.