학술저널
Cinmetacin의 amide유도체 합성과 항염진통촬성
Synthes and Antiinflammatory-analgesic Activity of Cinmetacin Amides
- 대한약학회
- 약학회지
- 제45권 제6호 (2001년)
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2001.12565 - 569 (5 pages)
- 7
Five novel cinmetacin amide derivatives as potential nonsteroidal antiinflammatory and analgesic compounds were prepared and their antiinflammatory-analgesic activity was compared with cinmetacin. Cinmetacin and hydroxysuccinimide were reacted with dicyclohexyl carbodiimide to give cinmetacin active ester (4), which was treated with amines to yield cinmetacin amides (5-9). Compounds (5) and (9) gave stronger analgesic activity than cinmetacin and compounds (5), (6), (9) showed comparable antiin1ammatory activity to cinmetacin.
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