학술저널
(S)-5-요오드 -2-아미노인단·염산염의 합성
Synthesis of (S)-5-iodo-2-aminoindan HCI
- 대한약학회
- 약학회지
- 제45권 제6호 (2001년)
-
2001.12582 - 587 (6 pages)
- 2
(S)-5-lodo-2-aminoindan HCI (7) was synthesized for developing a serotonergic agent. (S)-Phenylalanine was protected with trifluoroacetyl group and compound 2 was prepared by direct iodination in acetic acid and in the presence of I2, KIO4, and sulfuric acid. Compound 3 was cyclized by Friedel-Crafts reaction and reduced with NaBH4 to form 5-iodo-2-(N- trifluroacetyl) aminoindan-1-ol (4) . This compound was reduced to indan derivative 5 using the triethylsilane and BF3 · Et2O. It was basified with K2CO3 solution and treated with saturated HCI in ethyl ether to isolate compound 7.
(0)
(0)