구절호에서 분리한 linarin의 생리활성

Biological Activities of Linarin from Chrysanthemum zawadskii var. latilobum

Chrysanthemum zawadskii var. latilobum (Compositae), which is called Gu-lul- Cho, has been used as traditional medicine in pneumonia, bronchitis, common cold, pharyngitis, bladder-related disorders, women's diseases, and hypertension, etc. In this study, we have investigated various biological activities of methanol extracts and their main component, linarin isolated from this herb. The antipyretic erect of them was tested by Brewers yeast method and the antiinf1ammatory activities, with arachidonic acid, o-tet-radecanoylphorbol 13-acetate and carrageenan. Their antipretic and antiinflammatory activities were more potent than acetaminophene and aspirin. They also showed stronger hepatoprotective activities than ones of silymarin in mice.