영지버섯 균사체 (Ganoderma lucidum IY009)로부터 추출한 단백다당체의 항암활성

Antitumor Activities of the Proteoglycans from the Mycelium of Ganoderma lucidum IY009

In this study, the antitumor activities were investigated using β-Immunan, a proteoglycan obtained from cultured mycelia of the IYO09 strain of Ganoderma lucidum IY009belonging to basidiomycetes. The result showed the significant effect of cytotoxicity test against murine sarcoma 180 and murine Iymphocytic leukemia L1210 using immunized macrophage cultures by β-Immunan. When intraperitoneally injected at 40 mg/kg/day daily for 10 days, β-Immunan inhibited the growth of sarcoma 180 solid tumor in ICR mice by 88.8% (p<0.05). It was also observed that β-Immunan increased life span by 85.2% (p<0.01) after treatment of 100 mg/kg/day in BDFI mice bearing Iymphocytic leukemia L1210. And combination therapy with cisplatin (dosage: 4 mg/kg) increased life span by 140.4% (p<0.05) after treatment of 100 kg/mg/day in BDFI mice bearing Iymphocytic leukemia L1210.