Ethanol이 횐쥐의 복강비만세포에서 Histamine유리에 미치는 영향

Effect of Ethanol on Histamine Release from Rat Peritoneal Mast Cells

To investigate action of ethanol on histamine release from rat peritoneal mast cells, we compared the inhibitory effect of ethanol with those of calcium antagonists in mechanism of between ATP and compound 48/80-induced histamine release. Ethanol dose- dependently inhibited 1007M ATP-induced histamine release, whereas did not inhibit 1 mcg/ml compound 4a/80-induced histamine release. Verapamil,TMB-8 and EGTA dose- dependently inhibited ATP-induced histamine release, but did not inhibit compound 48/80-induced histamine release. Such an inhibitory effect of calcium antagonist was similar to that of ethanol. These results suggest that the inhibitory effect of ethanol on histamine release from rat peritoneal mast cells is mediated via disturbance of calcium mobilization.