Dopamine D2 Receptor차단제인 Raclopride의 신장작용

Renal Action of Raclopride, a Dopamine D2 Receptor Antagonist, in Dogs

This study was attempted to investigate the effect of raclopride, a dopamine D2 receptor antagonist, on renal function in dog. Raclopride (70∼ 220mcg/kg), when given intravenously ; Produced anticiuresis along with the decrease in free water clearance (CH2O), urinary excretion of sodium and potassium (ENa, EK), partially decreased osmolar clearance (Cosm) and increased reabsorption rates of sodium and potassium in renal tubules (RNa, RK). Raclopride administered into a renal artery did not inf1uence on renal function in small doses (10 and 30mcg/kg), whereas exhibited the decrease of urine volume (Vol) and CH2O both in experimental and control kidney in much dose (100mcg/kg), at this time, the decreased rates of both Vol. And CH2O were more prominent in control kidney rather than that elicited in experimental kidney and then only ENa was decreased in control kidney; but increased in eB7)erimental kidney: Raclopride administered via carotid artery (30-200mc/kg) did not influence at all on renal function. Antidiuretic action induced by raclopride given intravenously was not affected by renal denervation. Raclopride given into carotid artery was little effect on renal function without relation to renal denervation. Above results supe prest that raclopride produces antidiuresis by potentiation of antidiuretic hormone (ADH) action in blood without increase of ADH secretion in posterior pituitary gland, it is not related to renal nerve function in dogs.