토끼에서 체내담즙이 아세부톨를의 생체이용률 및 체내동태에 미치는 영향

Ehect of Bile juice on the Bioavailability and Pharmacokinetics of Acebutolol in Rabbits

Although acebutolol (ABT) is almost completely absorbed in the gastrointestinal (GI) tract, oral bioavailability of the drug is low due to extensive first-pass metabolism in the Gl tract and liver, In the present study; bioavailability and pharmacokinetics of ABT was studied in bile duct-bypassed rabbits after oral administration. For ABT the time to reach the plasma peak (Tmax) and mean resident time (MRT) were increased by the treatment. For diacetolol (DAT), a metabolite of ABT area under the plasma concentration-time curve (AUC), T max and plasma half-life were increased by the treatment. These results indicate that oral bioavailability of ABT is associated with the enterohepatic recycling of bile juice components.