HCI에 의한 식도염에서 식도와 하부활약근의 점막과 근육세포의 염증변화

Inf1amma1ory Changes in Esophagus and Lower Esophageal of HCI-elicited Esophagitis in Cats

The underlying mechanism by which the reflux of gastric juice elicits oesophagitis remains unclear. To inverttigate iidlammatory response to HCI in tissue of esophagus and lower esophageal sphincter, experimental esophagitis was elicited by perfusion of 0.1 N HCI in cats. There was no difference in phospholipase A2 (PLA2) activity of tissue between control and esophagitis. Myeloperoxidase activity in esophagitis was significantly greater than that of control. However, his- tamine content in esophageal mucosa of esophagitis was significantly smaller than that of control. These findings suggest that inflammatory response to HCI in esophagitis is related to changes of myeloperoxidase activity and histamine rather than change of PLA2 activity.