학술저널
ryloxyallylthiopyridazine 유도체 합성
Synthe s is of Aryloxyallylthiopyridaz me Derivatives
- 대한약학회
- 약학회지
- 제46권 제2호 (2002년)
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2002.0489 - 92 (4 pages)
- 0
Allylthio group of the sulfur compounds of garlic oil plays an important role for prevention and treatment of hepatic diseases induced by toxic substances or carbon tetrachloride. Thus allylthio group as pharmacologically active group was introduced into pyridazine heterocycle ring. Aryloxyallylthiopyridazine derivatives were synthesized and their hepato-protective activities were screened in rat. The activities of these compounds were weaker than alkoxyallylthiopyridazine derivatives, which exhibit a superior hepatoprotective effect.
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