홍삼 산성 다당체의 마크로파지 및 자연살해세포의 활성화에 의한 항암작용

Anticancer Activities of Red Ginseng Acidic Polysaccharide by Activation of Macrophages and Natural Killer Cells

The composition of monosaccharides of acidic polysaccharide isolated from ethanol- insoluble and water-soluble fractions of red ginseng roots was analysed and its immunological activities were investigated. Red ginseng acidic polysaccharide (RGAP) was composed of glucose (26.1 mole %), arabinose (1.6 mole %), glucuroninc acid (51.8 mol %) and galacturonic acid (5.1 mole %) as determined by gas liquid chromatography: Addition of RGAP increased production of nitric oxide (NO) and tumor necrosis factor (TNF)- αin the rodent macrophage cultures. Peritoneal macrophages from RGAP-treated mice exhibited potent tumoricidal activities toward P8l5 and WEHI 164 tumor cells. It was also observed that concentrations of NO and RGAP in vivo stimulated tumoricidal activities of natural killer(NK) cells. Treatment with RGAP. Moreover treatment of RGAP in vivo stimulated tumoricidal activities of natural killer (NK) cells. Treatment with RGAP increased life span of sarcoma 180-bearing mice and decreased tumor weights of Bl6-tumor-bearing mice. These results suggest that activation of macrophages and NK cells serve to enhance in vivo anticancer activities of RGAR.