4,5-치환 3-alkoxy-6-allylthiopyridazine 유도체 합성

Synthesis of 4,5-substituted 3-alkoxy-6-allylthiopyidazine Derivatives

Through a modification of allicin structure a disagreeable odor and chemical instability of allicin can be improved. 3-Alkoxy-6-allylthiopyridazine derivatives exhibit a superior effect for prevention and treatment of hepatic disease s induced by carbon tetrachloride and aflatoxin B1 and leer prevention of human tissues from radiation. These compounds inhibit also efficiently SK-Hep-1 cell proliferation through induction of apoptosis. So another 4,5-mono- or di-substituted 3-alkyloxy-6- allylthlopyridazine derivatives were synthesized on purpose to and out SAR of allylthiopyridazine in hepatoprotective and hepatotherapeutic acitivitis and to develop more effective drug candidate.