완층 수용액 중 Aloesin의 전처방화 연구

Preformulation Study of Aloesin in Buffered Aqueous Solutions

The physicochemical properties of aloesin, which has been recently found to reduce ienal toxicity induced by sis-platin, were studied including solubility partition coefficient (Pcc), osmolality and stability. The solubility of aloesin was about 500 mg/ml, and the Pcc value for n-octanou/water was 1.01 7 +/- 0.03. The degradation of aloesin followed the pseudo-first-order kinetics and was dependent on temperature, pH and ionic strength. From the pH-rate profile, the optimal pH was found to be 2.0∼3.0. Some metal ions increased the degradation rate in the rank order of Mn 2+ > Fe3+ > Cu2+ > Fe2+. On the other hand, other metal ions such as Bi3+, Ba2+, Zn2+, Ni2+, Co2+ and Mi+ did not show the unfavorable effects. After autoclaving, aloesin contents remaining were 81.8-98.8% of initial concentrations depending on pH. The most stable pH was 3.98 in the autoclaving. Osmolality increased linearly as concentration increased.