정맥주입한 알콜이 횐쥐의 췌장 외분비에 미치는 영향

Effects of Intravenous Infusion of Ethanol on Exocrine Pancreatic Secretion of Rats

To investigate the effect of intravenous ethanol administration on pancreatic exocrine secretion, we measured volume and protein amount in pancreatic juice and assayed amylase activity and phospholipase A 2 activity in pancreatic fragments and serum. Acute pancreatitis Induced by obstruction of common bile-pancreatic duct (CBPD) and caerulein infusion (57g7g1hr) showed typical characteristics, such as hyperamylasemia and pancreatic edema and increase of phospholipase A 2 activity in pancreatic fragments and serum. Intravenous ethanol infusion (50 mgHg/hr) significantly stimulated pancreatic exocrine secretion, but such a stimulatory effect of ethanol disappeared at dose of 100 mg/kg/hr without typical symptoms of acute pancreatitis. In microscopic examination, there were no typical changes of edematous pancreatitis in ethanol administrated rats. These results suggest that acute ethanol administration has dual effect on exocrine pancreatic secretion: low dose of ethanol (50 mg/hg/hr) stimulates pancreatic exocrine secretion, whereas high dose of ethanol (100 mghg/hr) does not without typical changes of edematous pancreatitis.