둥굴레 추출물 및 분획의 과산화지질 생성 저해효과

Anti-lipid Peroxidative Effect of Extracts and its Fractions

The rhizoma of Polyonatum odoratum(Liliaceae) promotes the production of body fluid and relives dryness symptoms and has hypoglycemic effect. In order to evaluate the prevention of lipid peroxidative efficacy of P.odoratum, its extracts (Et2O and MeOH ex.) and its fractions (H2O, 20% MeOH,40% MeOH, 60% MeOH and 100% MeOH fr.) were measured by TBARS assay on rat liver 59 and human erythrofrte ghost membrane. The order of anti-lipid peroxidative effect was as follows : Et2O ex. >40% MeOH fr. >60% MeOH fr. >100% MeOH fr. Based on these results, we conclude that mombrane lipid peroxidation is inhibited iu yifrp by addition of P.odoratum Ether extract and its gradient MeOH fractions excepts H2O fr, and which have significant hepatoprotective activity in CC14-treated rats.