Polymannuronate의 급이가 고콜레스테를 급이 횐쥐의 혈청 및 간 지질 오성에 미치는 영향

Effects of Polymannuronate Feeding on Compositions of Serum and Liver Lipids in the High- Cholesterol Fed Rats

The cholesterol and fatty acid levels in serum and liver were compared in 4-week-old Sprague-Dawley male fed by addition of polymannuronate (M,5.0%), polyguluronate (G,5.0%), and polymannuronate and polyguluronate (MG, 2.5% to each) with by addition of cholesterol (1.0%). Feed efsciency by the addition of M, MG, and G was lower than cholesterol fed group (p<0.01). The liver weights were less in M, MG, and G fed groups than in cholesterol fed group (p<0.01). Triglyceride levels in serum and liver were 58.2-77.4% and 51.5-65.5% lower in M, G and MG fed groups than cholesterol fed group, respectivel7: T3tal-, LDL-, and free-cholesterol levels in serum and liver in M, MG, and G fed group were sisniscantly lower than cholesterol fed group. The cholesterol levels were the most reduced in M fed group. However, HDL-cholesterol level in serum was increased in M, MG, and G fed group (p<0.01). The of polyene levels were 47% higher in serum and 76% in liver in M fed group than in cholesterol fed group. The activities of GOT and GPT were lower in M, MG, and G fed group than in cholesterol fed group (p<0.01). Above the results demonstrate that supplementation of low molecular polymannuronate in diets improve physiologically lipid composition in serum and liver.