학술저널
루판 유도체의 합성 및 세포독성 -I
Lupane Derivatives-I: Synthesis and Cytotoxic Activity
- 대한약학회
- 약학회지
- 제46권 제5호 (2002년)
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2002.10295 - 300 (6 pages)
- 3
To observe the structure-activity relationship of lupane derivatives both on cytotoxic and aftiangiogenic activity twelve lupane derivatives were prepared; their antiangiogenic and cytotoxic activities were evaluated. Among them, four compounds were more cytotoxic than betulinic acid. Carboxylic acid at C28 seemed to be essential for cytotoxic activity. But, a selective cytotoxicity toward SK-MEL-2 was not observed. As for antiangiogenic activity none of the compounds except lupeol showed antiangiogenic activity at 30 μg/mL.
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