넘취 정유의 Murine Macrophage Raw 264.7세포에서 in vitro항염효과

in vitro Antiinflammatory Activity of the Essential Oil from Lingularia fischeri var. spiciformis in Murine Marcrophage Raw 264.7 Cells

In the present study, effects of essential oils isolated from various plants have been evaluated on lipopolysaccharide (LPS)-induced release of nitric oxide (NO), prostaglandin E2(PGE2) and tumor necrosis factor-α(TNF-α) by the macrophage RAW 264.7 cells. Among the tested essential oils, essential oil of Lingularia fischeri var. spiciformis (LF-oil) signifcantly inhibited the LPS-induced generation of NO, PGE2 and TNF-αIn Raw 264.7 cells. Consistent with these observations, the expression of inducible NO synthase (Inos) and cyclooxygenase (COX)-2 enzyme was inhibited by LF-oil in a concentration- dependent manner Thus, this study suggests that inhibition of release of Inos, COX-2 expression, and TNF-α By the essential oil of Lingularia fischer may be one of the mechanisms responsible for the anti-inflammatory effects of this medicinal plant.