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학술저널

Sulbactam 유도체의 베타락타마제 효소억제력과 베타락탐항생제 병용시 활성비교

β-Lactamase Inhibitory Activity and Comparative Activity of Sulbactam Derivatives Combined with β-Lactam Antibiotics

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In vitro β-lactamase inhibitory acclivity of 6-exomethylene sulbactam compounds (CH-120,130,140,145,150, 155) was compared with calvulanic acid, sulbactam and taaobactam. The inhibitory activity of CH-140 was stronger than surfbactam and davulanic acid against Type II, III, IV, TEM enzymes and stronger than tazobactam against Type IV enzyme. The inhibitory activity of CH-145 was stronger than sulbactam and clavulanic acid against Type I, II, III, IV, TEM enzpnes and stronger than tasobactam against Type III, IV enzymes. The in vitro antimicrobial activity of CH-140 and CH-145 combined with piperaciBlin and ceftriaxone was compared with the sulbactam and taaobactam against β-1actamase producing 31 strains. But Synergistic activity of CH-140 and CH-145 was inferior to tazobactam.

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