택란의 비만세포 매개 즉시형 알레르기 반응의 억제 효과

Ihibitory Effect of Lycopus lucidus on Mast Cell-Mediated Immediate-Type Allergic Reactions

The effect of aqueous extract of Lycopus lucidus Turcz. (Labiatae)(LLAE) on mast cell-mediated immediatetype allergic reactions was investigated. LLAE (0.01 to 1 mg/g) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80. LLAE (0.001 to 1 mg/g) also dose-dependently inhibited local anaphyBaKis activated by anti- dini-trophenyl DNP) IgE. When LLAE was pretreated at the same concentration with syatemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner, LLAE (0.001 to 1 mg/ml) dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of CAMP in human mast cell line (HMC-1) cells, when LLAE (1mg/ml) was added, aignificanoy was increased, compared with that of normal control. These results provide evideNes that LLAE may be benescial in the treatment of allergic diseases.