Multiple Low Dose Streptozotocin으로 유도된 고혈당 횐쥐에서 인삼, 상엽 단독 및 복합 처방의 항당뇨 효과

Antidiabetic Effects of Ginseng Radix Alba (GRA) and Mori Folium (MF) on Multiple Low Dose Streptozotocin-induced Diabetic Rats

We comnpared the hypog1ycemic effecta of Ginseng Radix Alba (GRA) and Mori valium (MF) in multiple low dose (MLD) streptozotocin(STZ)-induced diabetic rats. In order to induce hyperglycemic state 25 mg/kg of STZ was injected intraperitoneally for 5 consecutive days. SD rats were randomly divided into diabetic control and treament groups. Treatment groups were administered with either 500 mgrkg of GRA (G5OO), 500 mg/kg of MF (M500), or 250 mg/kg of GRA mixed with same dose of MF (GM250) for 3 weeks. Blood glucose level and body weigllt were measured every 5th day. G5OO and M5OO both significantly reduced blood glucose levels as compared to the diabetic control group (diabetic control, 458.3 +/- 25.4 mg/dl; G5OO, 275.0 +/- 12.0; M5OO, 278.0: +/- 15.4; GM250, 324.0 +/- 18.4). While body weight in diabetic control group was deceased slightly after 3 weeks, treatinent pups shawed gradual increases of body weight during 3 week-period. Plasma insulin level was increased by treament with GRA, but those levels in M5OO and GM250 groups were similar to the diabetic control (normal control, 32.0 +/- 13.09μIU/ml; diabetic control, 12.4 +/- 1.9; G5OO, 17.5 +/- 3.4; M5OO,11.1 +/- 3.2; GM250, 10.5 +/- 3.7). Urine glucose levels were also remarkably reduced in all treatment groups (normal control, 0.0 +/- 0.0g/day; diabetic control, 11.4 +/- 2.5; G5OO, 4.9 +/- O.2; M5OO, 5.7 +/- 1.6 : GM250,8.2 +/- 0.2). At the second and third week of the treatnent, flood and water intakes were determined. At the third week, flood and water intakes were significantly decreased in all teatment groups. Taken together we may conclude that GRA and MF alone may prevent or delay the development of hypoglycemia, however synergistic hypoglycemic activity was not be seen in group treated with mixed fro-mula of GRA and MF when compared to GRA or MF alone.