Vanadate의 혈소판 응집작용과 Vanadium Yeast의 억제효과

Vanadate-induced Platelet Aggregation and Inhibition Effect of Vanadium Yeast

It has been well known that vanadium shows various physiological and pharmacological properties such as an insulin-mimetic effect. In view of the reported toxic effects there is the problems that the safety margin is narrow because of its strong toxicity. Vanadate was tested for its ability to cause blood agfegation. Although vanadate or H2O2 alone had little effect on platelet aggregation, treatment of vanadate and H2O2 together induced platelet aggregation indicated that it was occurred by pervandate or hydroxyl radical produced from the reaction of vanadate and H2O2. It was dependent on extracellular Ca2+ ion. Platelet aggregation caused by vanadate and H2O2was inhibited by ascorbic acid, tocopherol, catalase, mannitol, and Tiron. In contrast to vanadate, vanadium yeast prepared by uptaking vanadate in yeast cells did not inducenm platelet aggregation in the presence of H2O2.