피부면역계 랑게르한스세포의 TNF-α생산에 대한 Pedunculagin의 효과

Effect of Pedunculagin in production of TNF-αof Langerhans Cells

Ellagitannins have been reported to enhance the immune system. In this study; the effects of pedunculagin on langerhans cells were examined. Pedunculagin, an ellagitannin from Alnus hirsuta var, microphyllais a novel Immunomodulator, Langerhans cell are known as the potent antigen presenting cell and elicit the Contact Hypersensitivity (CHS) response by presenting Ag to trafficking Ag- specific T cells within the skin. For determining the effects of pedunculagin on murine langerhans cell, the expression of TNF-Αmrna was examined by RT-PCR. As a result, the expression of TNF-u myNA was upregulated by pedunculagin. These results suggest that pedunculagin enhances TNF-u and could be used as an immunomodulator in skin immune system.