모발생장기 유도 C3H생쥐에 있어서 미녹시딜과 생약추출 혼합 조성물의 모발 재성장 유도 효능

Evaluation of the Herbal Extract Mixture for the Effects of Hair-Regrowth Compared to 30% Minoxidel; Elongation of Anagen Period on C3H Mice

The hair cycle consists of three phases, growth (anagen), involution (catagen) and quiescence (telogen) phases. In order to evaluate hair re-growth effect of herbal extracts mixture containing the 70% ethanol extracts of Polygoni Mulitiflori Radix, Mori Cortex Radix, Gingo Biloba Folium and Pine bud, we have examined the induction of the anagen phase and elongation of the anagen period using C3H mice. MorPhological examination was done by Hattori and Ogawa's method. Enzyme activites of γ-glutamyl transpeptidase (γ-GT) and alkaline phosphatase(ALP) was detected by Bessey-Lovry-Brock's method. Enzyme activity as a biochemical marker of cycle was investigated in the third hair cycle period of C3H mice after depilation. 3% Milnoxldll treated group and herbal extract mixture treated group were shown 3 days earlier initiation of anagen than control group. In cycling mousse skin, γ-GT activity is pronounced during anagen and greatly diminished during telogen. Herual extract mixture has shown promising hair re-growth efect on hair follicula cycles of C3H mice.