Bl6 Melanoma세포에서 Citrus Essential Oil이 Melanin 생성에 미치는 영향

Effects of Citrus Essential Oils on Melanin Production in Bl6 Melanoma Cells

This study is performed to investigate the effects of citrus essential oils on melanin production in Bl6 melanoma cells. Five kinds of citrus essential oils (Bergamot, Grapefruit, Lemon, Mandarin, Petigrain) did not have any influence on DPPH radical scavenger activity cell growth and cytotoxicity in Bl6 melanoma cells. Both mandarin and petigrain essential oils dose-dependently inhibited purified tyrosinase activity, but bergamot did not. In 1μM MSH-stimulated Bl6 melanoma cells, all of 5 citrus essential oils inhibited melanin production in a dose dependent manner. From the above results, it is possible that citrus essential oils may be development to be an anti-melanogenesis agent on the basis of their inhibitory effect on MSH-induced melanin production.