학술저널
2 위치가 치환된 5-니트로 Benzimidazole 유도체들의 Topoisomerase I 억제 활성
Topoisomerase I Inhibition of 2-Substituted 5-Nitrobenzimidazoles
- 대한약학회
- 약학회지
- 제47권 제3호 (2003년)
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2003.06125 - 129 (5 pages)
- 4
A stories of 2-phenyl-5-nitrobenzimidazoles substituted at the para positron of the 2- phenyl moiety was sinthesized & evaluated for their activity to inhibit topoisomerase I. The structure-activity relationship study revealed that neither the electronic nor lipophilic parameters were related to the topoisomerase I inhibition. A strict spatial requirement seems to be present for retention of topoisomerase I inhibition activity.
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