1,5-Diphenylhydantoins의 가수분해에 의한 N-Aryl Phenylglycine O-Alkyl Esters의 합성

Synthesis of N-Aryl Phenylglycine O-Alkyl Esters Using Hydrolysis of 1,5-Diphenylhydantoins

For the development of new synthetic method for unnatural amino acid esters, N- aryl phenylglycine O-alkyl esters 4a~I were synthesized through base-catalyzed hydrolysis of 1,5-diphenylhydantoins 1a~b and O-alkylation in 16~87% yield. An efficient and practical route for final 4a~I was that the starting materials 1a~b were heated in dil-meth-anol for 30 minute using sodium hydroxide or potassium hydroxide and evaporated. In addition, reaction mixture were refluxed for 1 h in DMF. All synthetic process from hydantoin to N-aryl phenylglycine O-alkyl esters 4a~1 could be carried out in one-pot without isolation of intermediates.