모세관 전기영동법을 이용한 베타차단제 -시클로덱스트린 포접화합물의 안정도상수 결정

Determination of Stability Constants for β-Blocker and Carboxymethyl-β-cyclodextrin Complexes by Capillary Electrophoresis

The stability constants for the inclusion complexes between carboxymethyl-β- cyclodextrin (CM-β-CD) and five β-blockers, such as atenolol (ATE), bisoprolol (BIS), metoprolol (MET), pindolol (PIN) and propranolol (PRO) were determined by capillary electrophoresis. The magnitude of stability was decreased as following order; PRO>MET>BIS> ATE>PIN. Among them PRO showed the highest affinity towards CM-β- CD with stability constants of 383 and 371 M-1 for (R)- and (S)-enantiomer respectively: PIN enantiomers showed the lowest stability towards CM-β-CD, while the selectivity between (R)- and (S)-enantiomer was higher than any other tested β- blocker.