학술저널
Ring-Closing Metathesis 반응을 이용한 새로운 4-메칠 아데닌 및 유라실 카보사이클릭 뉴크레오사이드의 합성
Synthesis of 4'a-C Methyl Branched Novel Adenine and Uracil Carbocyclic Nucleosides Using Ring-Closing Metathesis
- 대한약학회
- 약학회지
- 제47권 제5호 (2003년)
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2003.10271 - 275 (5 pages)
- 4
Easy and efficient synthetic route of novel 4'-C methyl branched carbocyclic nucleosides is described. The installation of alkyl and aryl groups at 4'-position of carbocyclic nucleosides were successfully made via sequential [3,3]- sigmatropic rearrangement and ring-closing metathesis (RCM) starting from simple ketones such as acetol. Adenine and uracil were coupled via Pd(0) catalyzed reaction, followed by desilylation to give novel compounds 13 and 14, respectively.
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