B16 Melanoma 세포에서 Phenylpropanoid 화합물이 Melanin 생성에 미치는 영향

Effects of Phenylpropanoid Compounds on Melanin Production in B16 Melanoma Cells

To investigate the relationship between structure and bioological activity of phenylpropanoids, we measured effects of phenylpropanoids on anti-oxidant activity. Although phenylpropanoids did not inhibit purified-tyrosinase activity, they significantly inhibited tyrosinase activity and melanin production in MSH-stimulated B16 melanoma cells. However, phenylpropanoids did not affect tyrosinase expression in MSH-stimulated B16 melanoma cells, which suggest that inhibition of MSH-induced melanin production was due to tyrosinase inhibition mediated via other signal pathways but not expression of tyrosinase. Phenylpropanoids also significantly inhibited both hyaluronidase and elastase activity, suggesting that phenylpropanoids plays an important role in anti-oxidant and whitening activity.