학술저널
2'-메칠 및 4'-하이드록시 측쇄를 가진 새로운 카보사이클릭 뉴크레오사이드의 합성
Synthesis of 2'-Methyl and 4'-Hydroxy Branched Novel Carbocyclic Nucleosides
- 대한약학회
- 약학회지
- 제47권 제6호 (2003년)
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2003.12417 - 421 (5 pages)
- 7
This paper describes a synthetic route to novel 2'-emthyl and 4'-hydroxy carbocyclic nucleosides. The methyl group was successfully installed by carbonyl addition reaction of isopropenyl magnesium bromide followed by ring-closing metathesis and the hydroxy group was directly introduced from carbohydrate chiral template "D-lactose".
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