학술저널
석창포 헥산 추훌물이 Staphylococcus aureus SA2의 Chloramphenieol Acetyltransferase에 미치는 영향
Effect of Hexane Extract of Acori graminei Rhizoma on Chloramphenicol Acetyltransferaseof Staphylococcus aureus SA2
- 대한약학회
- 약학회지
- 제48권 제1호 (2004년)
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2004.0230 - 33 (4 pages)
- 14
One subfraction from the hexane fraction of Acori graminei Rhizoma, the E4 fraction which is mainly consisted of acorenone, showed a potential inhibitory activity against chloramphenicol acetyltransferase (CAT) of S. aureus SA2 that is a multidrug-resistant strain to 10 usual antibiotics. The combination therapy of this fraction with chloramphenicol resulted in reduction of the minimal inhibitory concentration from 128 μg/ml to 8 μg/ml. The E4 fraction also revealed to prevent the induction of CAT from this strain.
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